RJ Hamster
Early trial data shows 63.7% reduction in cancer burden
Most cancer breakthroughs are measured in charts. This one is visible under a microscope.
Time-lapse footage from a recent clinical study shows immune cells attacking and eliminating cancer cells.
These are Natural Killer (NK) cells, the part of the immune system tasked with identifying and destroying abnormal cells before tumors spread.
But in advanced cancers, they can become depleted. When they do, tumors regain control.
One NASDAQ-listed biotech is building its platform around amplifying these cells.
Its TriKE® platform is designed to keep NK cells active longer – fueling them to stay locked onto cancer cells.
In side-by-side comparisons, the effect was clear:
NK cells alone slowed tumors. But when combined with the company’s TriKE® technology, cancer cells declined sharply.
Early human data showed up to a 63.7% reduction in cancer burden.
Now the company’s next-generation version, showing potential for 10-40× greater potency, has cleared an important FDA milestone.
Watch the microscopic footage and learn more
about the company’s next catalyst.
Market Tactic
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Avis, CarMax, and Carvana: 3 Car Stocks Sharply Diverge
Reported by Leo Miller. Originally Published: 4/20/2026.
Key Points
- Avis Budget Group is shooting to the moon as short sellers take big hits.
- CarMax remains down significantly as it loses market share.
- Meanwhile, Carvana is taking share, putting the stock heavily in the green over the past 52 weeks.
- Special Report: Elon Musk: This Could Turn $100 into $100,000
Car rental and used-car stocks are showing a wide divergence in performance. Three notable names across these industries are Avis Budget Group (NASDAQ: CAR), CarMax (NYSE: KMX), and Carvana (NYSE: CVNA). Over the past 52 weeks, returns among these stocks range from declines of about 30% to gains approaching 500%. Below, we break down what’s driving the divergent performance and what Wall Street analysts are saying.
Avis Catapults on Suspected Short Squeeze
Over the past 52 weeks, Avis Budget Group has gained more than 450% and is approaching the 500% mark. Since the end of March alone, Avis shares are up more than 200%, and the stock has posted nine single-day gains of 10% or more. Analysts have largely attributed the explosive rise to a suspected short squeeze.
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Short squeezes occur when a large portion of a company’s floated shares are sold short. As the stock rises, short sellers are forced to buy shares to cover positions, which can push the price higher and trigger further short covering.
At the end of March, short interest in Avis was roughly 54% of the float — an extremely high level that makes the stock a prime short-squeeze candidate. More recent reports indicate short interest has risen to about 58%, suggesting new traders are entering short positions even as the stock climbs.
That said, betting on potential short squeezes is very risky. Stocks driven by such technical dynamics can fall as quickly as they rise because fundamentals often don’t support the valuation. For example, Avis’s revenue fell 1% in 2025, yet the stock trades at a forward price-to-earnings ratio near 130X. Wall Street analysts remain broadly bearish: the MarketBeat consensus price target of $115 implies roughly 75% downside from current levels.
CarMax Sees Big Losses Amid CEO Departure, Falling Sales
Used-car reseller CarMax is down more than 30% over the past 52 weeks and has experienced several steep single-day drops during that span. One notable decline came in November 2025, when the company announced its CEO would step down and provided weak guidance.
At that time, CarMax projected comparable sales would fall 8% to 12% in its Q3 fiscal 2026. (CarMax’s fiscal calendar is offset from the calendar year.) The company also forecast EPS between $0.18 and $0.36, while analysts expected a comparable sales decline near 3% and EPS above $0.60.
When CarMax reported, it posted a comparable sales decline of 9% and EPS of $0.43. Those results were slightly better than the company’s midpoint guidance, but the stock still sold off. Even after CarMax beat expectations in April 2026, the shares dropped another 15%, reflecting lingering investor skepticism about the company’s longer-term outlook.
Analysts remain cautious. The MarketBeat consensus price target of $41.21 suggests the shares are roughly fairly valued, but price targets updated after the latest earnings report average about $35.50, implying more than 10% downside.
Carvana Grows Car Sales by 43% as CarMax Declines
CarMax’s weakness coincides with Carvana’s rapid growth. CVNA is up more than 80% over the past year as the company takes share from legacy resellers. In 2025, Carvana sold 596,641 cars to retail customers, a 43% year-over-year increase. By contrast, CarMax sold 780,684 cars in FY2026, a 1.1% decline from the prior year. One year earlier, Carvana sold 416,348 retail vehicles versus CarMax’s nearly 789,050 — highlighting how quickly Carvana’s customer base has expanded while CarMax’s has contracted.
Unlike CarMax’s network of more than 250 traditional showrooms, Carvana has no physical stores: buying and selling happens online, the company picks up cars from sellers, refurbishes them, and delivers purchases to buyers. Given recent results, Carvana’s model appears to be resonating with consumers.
Analysts are moderately bullish on Carvana. The MarketBeat consensus price target near $435 implies roughly 10% upside. However, several targets updated in April are lower — the April average so far is $411 (about 5% upside) — and individual targets range from $335 to $475. Carvana’s Q1 2026 report, scheduled for late April, could prompt further revisions.
Avis Stands Alone, CarMax and Carvana Jockey for Share
Avis Budget Group’s recent move appears driven primarily by technical trading rather than changes in its rental-car market position. By contrast, CarMax and Carvana illustrate two ends of the same resale-market shift: Carvana’s online, asset-light model is gaining traction while CarMax’s traditional showroom network faces pressure.
Carvana also has ambitious long-term targets, aiming to reach 3 million annual retail vehicle sales between 2030 and 2035 — a goal that would require sustained annual growth in the roughly 18%–38% range.
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Powering Up: UGI Banks $685M in Strategic Turnaround
Reported by Jeffrey Neal Johnson. Originally Published: 5/4/2026.
Key Points
- UGI Corporation is executing a formalized business turnaround by divesting non-core assets to improve its financial health and sharpen its focus.
- A significant infusion of capital from recent asset sales is being used to aggressively deleverage the balance sheet and secure UGI Corporation’s dividend.
- Profitability in UGI Corporation’s core gas segments is improving, suggesting positive operational momentum for the newly streamlined enterprise.
- Special Report: Elon Musk: This Could Turn $100 into $100,000
Utility sector investors often prioritize balance sheet stability and dividend security above all else. A strategic shift is underway at UGI Corporation (NYSE: UGI) that appears designed to deliver on both. UGI is executing a significant capital-optimization plan—anchored by the recent divestiture of its Pennsylvania electric division—to aggressively deleverage and sharpen its focus on core energy distribution businesses.
That operational pivot could offer a compelling entry point for investors seeking a discounted utility with renewed capital discipline and a secure, high-yield dividend.
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The cornerstone of the initiative is the definitive agreement announced on April 28, 2026 to sell UGI’s Pennsylvania Electric Division to funds managed by Argo Infrastructure Partners. The transaction will inject roughly $470 million in cash, which management has earmarked for debt reduction. The sale divests UGI of 2,700 miles of transmission lines and 14 substations, marking a decisive exit from a capital-intensive, regulated electricity business. It is also UGI’s second major transaction with Argo in the past 12 months, underscoring an established execution pathway for future portfolio adjustments.
The divestiture complements a methodical withdrawal from its European LPG business, transactions that added about $215 million to the liquidity pipeline. Combined, these sales provide UGI with roughly $685 million to strengthen its balance sheet, a meaningful sum relative to its $8.07 billion market capitalization.
Forging a Fortress Balance Sheet
The immediate result is a cleaner, more resilient financial profile. For a utility, lower leverage improves operational flexibility, reduces risk in turbulent macroeconomic periods, and can lower the cost of capital by improving credit metrics. Interest expense savings can flow to the bottom line, boosting earnings and cash flow available for reinvestment or shareholder returns. For equity holders, stronger credit metrics directly enhance dividend security.
UGI maintains a 37-year record of consecutive dividend increases, reflecting long-term stability. The current annualized dividend of $1.50 per share yields about 4.2%. The payout ratio stands at a sustainable 55% of trailing earnings and roughly 25% of cash flow, indicating the distribution is well-supported and has room to grow as the company’s turnaround and deleveraging efforts take hold.
Turnaround Unspooling: Core Profitability Is on an Upward Trend
A surface-level read of UGI’s most recent Q1 2026 earnings report might give investors pause. UGI reported EPS of $1.26, missing the analyst consensus of $1.50. While quarterly revenue rose 2.6% year over year to $2.08 billion, the EPS shortfall merits a deeper look at operational performance.
Below the headline, the core business shows strength. Reportable segment earnings before interest and taxes (EBIT) grew 5% year over year to $441 million. That improvement was driven mainly by new base rates for the Pennsylvania natural gas division and a 16% increase in core market volume, indicating improving profitability in UGI’s primary natural gas and propane segments despite non-operational headwinds affecting EPS.
Management has framed 2026 as a turnaround year. CEO Robert Flexon and the February appointment of Sidd Manjeshwar as Chief Strategy Officer reflect leadership alignment behind a deliberate plan to optimize the asset portfolio for long-term value creation.
Why UGI Trades at a Steep Discount to Its Peers
Valuation also supports the investment case. UGI trades at a trailing P/E of 13x and a forward P/E of 12x, a meaningful discount to many peers. For example, Atmos Energy Corporation (NYSE: ATO)trades closer to 25x. That valuation gap likely reflects lingering market skepticism from past performance and the company’s previously complex business mix. It could narrow if UGI successfully executes its deleveraging plan and the market recognizes a leaner, more stable enterprise.
Wall Street sentiment is cautiously optimistic. The consensus among five analysts is a Moderate Buy, with an average price target of $42—about 18% upside from the early-May share price.
Risks remain. UGI is navigating rate cases with the Pennsylvania Public Utility Commission, and outcomes will be key to future margin expansion. Additionally, insider transaction data shows net selling of $1.26 million over the past 12 months. While much of that appears tied to planned compensation, it is worth monitoring.
Strategically Reengineering Toward a Sharper Focus
UGI’s recent moves represent a clear pivot toward its core strengths in natural gas and propane distribution. The roughly $685 million from asset sales provides an immediate lever to strengthen the balance sheet. That financial discipline, combined with improving underlying operations and a discounted valuation, makes a persuasive case for investors seeking stable, high-yield utility exposure.
Investors may want to add UGI Corporation to their watchlist. The company’s formal turnaround efforts, backed by tangible strategic divestitures, appear to position it for a period of improved financial stability and potentially enhanced shareholder returns.
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Daily Bonus Content: Why Kevin Warsh is so good for this coin(From Crypto 101 Media)
