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From RSV to Smallpox: NNVC’s NV-387 Could Have a Breakout Year!

Viruses are fueling a global public health crisis, from a severe flu season to a recent measles scare, leaving the world grappling with an unprecedented viral burden. 

Amid this, NNVC—a small but groundbreaking biotech—is aiming to redefine how we fight infectious diseases!

Viruses still run the clock. This winter has been an uncomfortable reminder that viruses don’t care about market cycles or policy debates. The current flu season has been labeled “moderately severe,” with millions of illnesses, rising hospitalizations, and thousands of deaths already recorded. 

At the same time, public concern flared after a measles case was recently linked to a visit to Disneyland! A stark illustration of how quickly infectious diseases can resurface in crowded, globalized environments.

Despite decades of medical progress, society remains largely reactive when it comes to viral outbreaks. Vaccines lag evolving strains, antiviral drugs lose effectiveness as resistance builds, and physicians often have limited options beyond supportive care. 

The need for a durable, broad-spectrum solution has never been clearer — and this is where NanoViricides (NYSE: NNVC) enters the conversation.

This is Why NanoViricides (NYSE: NNVC) Could Become One of the Most Important Biotech Stories in the Market!

The Problem — A World Still Vulnerable to Viral Outbreaks

Influenza alone continues to expose the limits of current medical defenses. This season, the dominant H3N2 strain differs from the strain targeted by the annual flu vaccine, reducing vaccine effectiveness and leaving many patients exposed. Existing antiviral treatments like Tamiflu and Xofluza must be administered within a narrow window and are increasingly threatened by viral resistance.

This pattern repeats across respiratory illnesses. RSV has no broadly approved treatment. Coronaviruses continue to mutate. Each year brings a new scramble to catch up, rather than a lasting solution that can stay ahead of viral evolution.

What NanoViricides Is Trying to Do Differently

NanoViricides, Inc. (NYSE: NNVC) is a clinical-stage biotechnology company focused on developing a new class of antiviral drugs designed to solve the resistance problem altogether!

Rather than targeting the virus directly in ways that encourage mutation, NNVC’s approach mimics key features of human cell surfaces that viruses must bind to in order to infect the body.

Its lead drug candidate, NV-387, is designed to act as a decoy — luring viruses to attach to it instead of real cells, then neutralizing them. Because viruses rely on these same binding mechanisms regardless of mutation, the company believes NV-387 is highly unlikely to be “escaped” through normal viral evolution.

NV-387 and Broad-Spectrum Antiviral Potential

According to NNVC, more than 90% of human pathogenic viruses use heparan sulfate or related features to infect cells. NV-387 copies these features and presents them in abundance, effectively trapping virus particles before they can cause harm.

Preclinical studies have shown NV-387 to be highly effective against Influenza A/H3N2, outperforming both Tamiflu and Xofluza in animal models of lethal lung infection. 

The drug has also demonstrated activity against RSV and coronaviruses — the same trio responsible for the so-called “tripledemic” of recent winters.

NNVC believes this positions NV-387 as a potential first-line, symptom-based therapy for respiratory viral infections, allowing physicians to treat patients without waiting to identify the specific virus involved — a paradigm shift in antiviral medicine!

A Breakthrough Approach Against RSV

Respiratory syncytial virus (RSV) is a serious respiratory infection that poses a major threat to infants, young children, the elderly, and immunocompromised adults, causing severe lung infections, hospitalizations, and, tragically, deaths every year. 

Unlike the flu or COVID-19, there are currently no fully effective treatments for RSV, leaving doctors with limited options beyond supportive care. 

This is where NanoViricides (NNVC) stands out: its lead candidate NV-387 has shown complete cures in lethal RSV animal models, demonstrating a level of efficacy no existing antiviral can match. 

By mimicking human cell surfaces to trap and destroy viruses, NV-387 attacks RSV in a fundamentally new way that viruses cannot evade, offering hope for a drug that could dramatically reduce RSV’s deadly impact on the most vulnerable populations.

The Opportunity — A Large Market, If the Science Holds

If approved for broad use in acute and severe respiratory infections, NV-387 could address a market estimated by the company to exceed $20 billion. Beyond seasonal flu, the drug could play a critical role in future outbreaks, including potential bird flu variants where resistance to existing antivirals is expected to emerge quickly.

NanoViricides Kicks Off Phase II Mpox Trial for NV-387, Signaling a Key Milestone for Broad-Spectrum Antivirals

NNVC is now entering a critical stage in its clinical development, with Phase II trials for its lead antiviral candidate NV-387 officially cleared to begin in the Democratic Republic of Congo with ACOREP approval. 

NV-387, which completed Phase I in healthy volunteers with no reported adverse events, has already demonstrated remarkable broad-spectrum efficacy in animal studies, including complete cures in lethal RSV models and superior performance versus existing influenza therapeutics like Tamiflu and Xofluza. 

The start of this Phase II Mpox trial marks a major inflection point, not only for NanoViricides’ pipeline but for the antiviral space as a whole, as NV-387 could potentially address multiple viral threats—including Influenza, RSV, Coronaviruses, smallpox, and measles—using its innovative nanoviricide platform. 

With this trial underway, NNVC has entered a phase where real clinical data will begin to validate its revolutionary approach, making the company one to watch closely for investors and biotech observers seeking the next breakthrough in antiviral medicine.

Why This Is Important

This milestone is significant because MPox currently has no reliably effective treatments, and recent outbreaks—including community spread of Clade I in the U.S.—highlight the urgent need for antiviral solutions. 

NV-387’s broad-spectrum design could target the majority of human pathogenic viruses, offering a potential first-of-its-kind therapy for MPox and other viral infections. Regulatory approval to advance into Phase II trials not only validates the scientific promise of NNVC’s platform but also positions the company as a potential leader in antiviral innovation, setting the stage for future clinical and commercial breakthroughs.

The Next Biotech Breakthrough?

In 2026, biotech companies are under intense scrutiny as investors and the broader public alike seek solutions to enduring and emerging health threats, from persistent respiratory viruses to global pandemics. The sector has captured attention not just for its potential to deliver high-growth returns but for its real-world impact on public health outcomes. 

Within this spotlight, NanoViricides (NNVC) stands out as a potential breakthrough winner because it is developing something fundamentally different from traditional antivirals: a broad-spectrum platform designed to neutralize viruses at the very point of cellular entry, a vulnerability nearly all pathogenic viruses share. 

Should its lead candidate, NV-387, prove successful in clinical trials, it could redefine antiviral therapy and position NanoViricides not just as a biotech success story of 2026, but as a pivotal force in shaping the future of how viral infections are prevented and treated!

The Bottom Line

NNVC represents the kind of opportunity that may reward patience.

If  NV-387 delivers on its promise, the payoff could be transformative — not just for shareholders, but for how viral diseases are treated worldwide.

In a world where bad flu seasons, surprise measles cases, and emerging viruses continue to disrupt daily life, the demand for a true broad-spectrum antiviral solution is undeniable. NanoViricides is attempting to meet that demand with a novel approach that, if successful, could mark a turning point in antiviral medicine.

NNVC may be less about timing the market — and more about waiting for science to catch up with a very big idea! Start your research!

We are issuing this disclosure in compliance with Section 17(b) of the Securities Act, which requires us to disclose any compensation received or expected to be received in cash or in kind in connection with the purchase or sale of any security.

We would like to inform you that we have received or expect to receive compensation in connection with the purchase or sale of the securities of NanoViricides, Inc. (NYSE American: NNVC). The compensation consists of up to $6,500 and was received/will be received from Interactive Offers.

This communication should not be considered as an endorsement of the securities of adviser NanoViricides, Inc. (NYSE American: NNVC) and we are not responsible for any errors or omissions in any information provided about the securities of NanoViricides, Inc. (NYSE American: NNVC) and Interactive Offers.

We encourage you to conduct your own due diligence and research before making any investment decisions. You should also consult with a financial advisor before making any investment decisions.

This disclosure is made as of 02/13/2026.

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