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Jeff Ackerman Announces (CVKD) Will Be Topping Our Watchlist

Tomorrow—Monday, January 26, 2026.

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(CVKD) Comes Backed By 7 Must See Potential Catalysts

Full Coverage Will Be Starting Early

Pull Up (CVKD) Before Tomorrow Morning…

January 25, 2026

Monday’s Spotlight | See Why (CVKD)Just Hit Tomorrow Morning’s Watchlist

Dear Reader,

Every so often, a small company quietly steps into a space dominated by giants not by chance, but by bringing something fundamentally new to the table.

In the race to solve one of medicine’s longest-running challenges—preventing dangerous clots without increasing bleeding risk—one emerging player continues to make moves that could reshape the anticoagulation landscape.

In a $40B global market that has seen limited real innovation in decades, that kind of progress is hard to overlook.

That company is Cadrenal Therapeutics, Inc. (Nasdaq: CVKD).

And it’s just one of the reasons why (CVKD) will be topping our watchlist tomorrow morning—Monday, January 26, 2026.

We’re covering it for the first time, and its expanded clinical assets, operational milestones, and broader pipeline footprinthave put it on our watchlist.

What caught our attention is the technical setup of (CVKD).

(CVKD) has less than 2M shares listedas available to the public. When a company has a small float like this, the potential exists for big moves if demand begins to shift.

We have already seen this momentum in action, as (CVKD) made an approximate 36% move from $6.42 on December 30, 2025, to $8.79 on January 14, 2026.

Analyst Target Suggests Over 500% Upside Potential

The expansion of the pipeline has led to strong reaffirmations from one research firm.

Noble Capital Markets: Senior Analyst Robert LeBoyer recently reiterated a Bullish rating with a $45 target on (CVKD).

From its recent $7 range, this suggests a potential upside of over 500%. LeBoyer specifically cited the $3B+ peak annual revenue potential of the targeted indications.

Now here’s the key point: the recent attention isn’t coming from a single headline or a one-off catalyst—it’s coming from what the company is building underneath the surface.

In a category where most names are still fighting the same old tradeoffs, (CVKD)is pushing into areas where better tools are still badly needed.

And the further you go into the story, the clearer it becomes why this one could start showing up on more screens right now.

Bridging Critical Gaps in Cardiovascular Care

Cadrenal Therapeutics, Inc. (Nasdaq: CVKD) is a late-stage biopharmaceutical company focused on addressing unmet needs in the anticoagulation and thrombosis space.

While the broader market is saturated with therapies, many patient populations remain underserved due to high bleeding risks or unpredictable metabolism.

(CVKD) is specifically targeting these gaps with a platform that spans chronic care, acute procedural risk, and immune-mediated thrombosis.

The company’s primary focus has long been tecarfarin, a next-generation vitamin K antagonist designed for patients with End-Stage Kidney Disease (ESKD) and atrial fibrillation. These patients often cannot use modern therapies like DOACs because they are primarily eliminated by the kidneys.

By developing a therapy that is metabolized outside the major hepatic pathways, (CVKD) aims to provide more stable and predictable anticoagulation for those who need it most.

In late 2025, (CVKD) transformed from a single-asset company into a multi-program clinical powerhouse.

The company recently acquired first-in-class assets that address acute care and rare immune-driven clotting conditions. This expansion has positioned (CVKD) as a versatile player in cardiovascular care, targeting conditions where current therapeutic options often fall short.

A Specialized Pipeline Built for High-Stakes Environments

The core thesis for (CVKD) rests on itsdiversified pipeline, which now features three distinct late-stage programs.

The VLX-1005 Breakthrough:

On December 11, 2025, (CVKD)announced the acquisition of VLX-1005, a first-in-class Phase 2 12-LOX inhibitor. This candidate targets Heparin-Induced Thrombocytopenia (HIT), a serious immune-mediated complication of heparin therapy that can lead to life-threatening clots.

VLX-1005 is the first and only potent, highly selective inhibitor of human 12-LOX in clinical testing. This asset carries both FDA Orphan Status and Fast Trackdesignations, which are intended to expedite the development of therapies for rare and serious conditions.

During the January 2026, J.P. Morgan Healthcare Conference, management highlighted the high incidence of thrombotic complications in HIT, underscoring the urgent need for a therapeutic solution like VLX-1005.

Expanding with Factor XIa Inhibition:

The company also added frunexian and EP-7327 to its portfolio in September 2025. Frunexian is a Phase 2-ready intravenous Factor XIa inhibitor designed for acute procedural scenarios, such as bypass surgery or mechanical device support where contact activation triggers clotting.

Factor XIa inhibition is a closely watched mechanism because it may reduce clotting risk while limiting bleeding, a major hurdle for existing anticoagulants.

Detailed Program Breakdown:

To appreciate the scale of what (CVKD) is building, one must look at the specific indications and the science driving each program.

Tecarfarin (Phase 3-Ready):

• Mechanism: Next-generation oralvitamin K antagonist.
• Indication: Targeted at patients with ESKD and AFib, and those with Left Ventricular Assist Devices (LVADs).
• Status: Manufacturing has been completed under current good manufacturing practices (cGMP).
• Differentiator: It bypasses the CYP450 metabolism pathway, reducing the risk of drug interactions and providing a more stable therapeutic window.

Frunexian (Phase 2-Ready):

• Mechanism: IV Factor XIa inhibitor.
• Indication: Coronary Artery Bypass Grafting (CABG) and other device-driven contact activation scenarios.
• Evidence: Phase 1 studies demonstrated high potency and rapid clearance, making it ideally suited for the acute care environment.
• Potential: Aims to eliminate the “bleeding penalty” associated with traditional anticoagulants in surgical settings.

VLX-1005 (Phase 2):

• Mechanism: 12-LOX inhibitor.
• Indication: Heparin-Induced Thrombocytopenia (HIT).
• Significance: HIT remains a life-threatening condition with a high risk of thrombosis despite available therapies.
• Regulatory: Holds FDA and EMA Orphan designations plus FDA Fast Track status.

And this is where the story starts to shift from “interesting pipeline” to “company people are suddenly paying attention to.”

(CVKD) isn’t just assembling programs on paper—it’s stacking clinical and operational signals that the market tends to notice when they show up together.

When a little-known company, like (CVKD), begins pairing late-stage readiness with fresh assets in high-need settings, visibility can change fast.

Strategic Milestone: The J.P. Morgan Healthcare Conference

The presentation at the J.P. Morgan Healthcare Conference on January 12, 2026, was a pivotal moment for the company’s visibility.

Management used this stage to emphasize that HIT is not just a rare condition but a high-incidence complication that lacks a “gold standard” treatment.

By positioning VLX-1005 as the first and only selective 12-LOX inhibitor, (CVKD is effectively claiming leadership in a niche but highly critical segment of hospital-based medicine.

Furthermore, the company has emphasized its manufacturing progress. Completing cGMP manufacturing for tecarfarin is a major hurdle cleared.

This move signals that (CVKD is not just a research house but an operationally ready late-stage clinical developer capable of moving into pivotal trials.

The “Emergency Response” Philosophy

As noted in recent updates, the CVKDpipeline is beginning to look less like a typical biotech and more like an “emergency response system” for the cardiovascular ward.

Whether it is a patient suffering from HIT, a patient undergoing a CABG procedure, or an ESKD patient needing long-term protection from AFib, CVKD is developing specific tools for specific crises.

This “layered approach” is something few emerging companies can match, as most focus on a single mechanism or a single indication.

7 Reasons Why (CVKD) Will Be Topping Our Watchlist Tomorrow Morning —Monday, January 26, 2026.

1. Razor-Thin Float: With fewer than 2M shares available to the public, (CVKD)’s small float could witness the potential for big moves if demand begins to shift.

2. Analyst Coverage: Analyst’s $45 target on (CVKD) suggests over 500% upside potential from recent levels.

3. Triple-Asset Platform: Following its recent acquisitions, (CVKD) now advances three late-stage clinical programs spanning chronic, acute, and immune-mediated cardiovascular risk.

4. First-in-Class: By adding VLX-1005, (CVKD) now holds the only selective 12-LOX inhibitor currently in clinical testing, aimed at HIT.

5. Late-Stage Readiness: With tecarfarin progressing toward a pivotal study in ESKD, (CVKD is entering a phase that could determine outcomes for high-need patient groups.

6. Regulatory Fast Tracking: The Orphan and Fast Track designations for VLX-1005 help (CVKD) push forward in a rare condition with limited therapeutic options.

7. Massive Market Potential: By targeting underserved niches within the $40B anticoagulation market, (CVKD)is positioning itself where few emerging companies have comparable breadth.

Pull Up (CVKD) Before Tomorrow Morning…

(CVKD) stands out because of several potentially “attention-getting” elements are lining up at the same time: a razor-thin share float, a broadened three-program platform across chronic, acute, and immune-driven clotting risk, and a late-stage path that includes tecarfarin moving toward a pivotal study in ESKD.

Add in VLX-1005—described as the only selective 12-LOX inhibitor currently in clinical testing for HIT—with Orphan and Fast Track designations, and you can see why this name is starting to appear on more screens.

When you pair that kind of pipeline breadth with a market the company describes as roughly $40B, it’s easy to understand why the analyst’s target suggests over 500% upside potential.

are publishing aggressive target frameworks and why momentum-focused readers are paying attention to (CVKD).

We will have all eyes on (CVKD)tomorrow morning—Monday, January 26, 2026.

Take a look at (CVKD) before you call it a night.

Also, keep a lookout for my morning update.

Have a good night.

Sincerely,

Jeff Ackerman
Managing Editor
Stock News Trends

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