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January 25, 2026

Heads Up | Here’s 7 Reasons Why (TLSA) is Topping Monday’s Watchlist

Dear Reader,

The landscape of neurological medicine is shifting as a single biotech firm advances a delivery method that could change how we address some of the most stubborn diseases of the human brain.

Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) is currently at the center of this transition, utilizing a unique intranasal approach to treat neurodegenerative conditions that have long lacked effective solutions.

With a recent peer-reviewed publication and a surge in institutional support, this company is demanding the attention of anyone monitoring the future of biotechnology.

And that’s just some of the reasons why (TLSA) will be topping our watchlist tomorrow morning—Monday, January 26, 2026.

Even at this early stage, (TLSA) is starting to stand out as one of the more closely followed names in neuro-immunology, thanks to a delivery approach that directly addresses the central nervous system.

And now, outside observers are beginning to put hard numbers around what that progress could mean.

Analyst Target Suggests Over 400% Upside Potential

One analyst has begun to take note of the progress at Tiziana Life Sciences, Ltd. (Nasdaq: TLSA).

Recently, Elemer Piros, PhD, an analyst with Lucid Capital Markets, published a bullish rating on the company. Dr. Piros set an $8 target on (TLSA), which suggests a 406% potential upside from its recent price range of $1.58.

This valuation is largely driven by the potential of the Foralumab platform and its applicability across a potential $33B market.

The analyst community often looks forde-risking events, and the recent peer-reviewed data for SPMS is considered a major milestone. As the company moves toward Phase 2 results in both MS and Alzheimer’s, the potential for upward revisions in valuation remains high, especially if the safety profile continues to hold up in larger patient populations.

The Tiziana Approach to Neuro-Immunology

Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) is a clinical-stage biotechnology company headquartered in London and New York, dedicated to developingtransformative therapies that leverage the body’s own immune system. The company’s primary focus revolves around its proprietary platform for the intranasal delivery of monoclonal antibodies.

Unlike traditional intravenous methods, this nasal-to-brain route is designed to bypass the blood-brain barrier, potentially allowing for localized therapeutic effects in the central nervous system while minimizing systemic side effects.

The company operates in the high-stakesneuroscience market, specifically targeting Secondary Progressive Multiple Sclerosis (na-SPMS), Alzheimer’s disease, and Amyotrophic Lateral Sclerosis (ALS).

What makes (TLSA) distinctive is its lead candidate, Foralumab, which is the only entirely human anti-CD3 monoclonal antibody in clinical development.

By modulating T-cell responses and reducing neuroinflammation, (TLSA) aims to provide a new standard of care for patients who have exhausted traditional options.

Founded in 1998, the company has spent decades refining its approach toimmunotherapy. Its lean and virtual research model allows it to focus capital on high-value clinical activities rather than heavy overhead. This strategic structure has enabled TLSA to maintain a robust pipeline while advancing multiple orphan and large-market indications simultaneously.

The Scientific Foundation: Intranasal Foralumab

At the heart of Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) is the scientific conviction that neuroinflammation is a primary driver of disease progression in the brain. Foralumab works by binding to the T-cell receptor complex, specifically the CD3 epsilon subunit. When administered through the nasal cavity, the therapy is designed to stimulateregulatory T cells (Tregs) in the cervical lymph nodes.

These “calming” cells then migrate to the brain, where they work to dampen the activity of microglia—the immune cells of the central nervous system that, when overactive, cause tissue damage in MS and Alzheimer’s patients.

This mechanism of action is a radical departure from traditional treatments. Most current MS therapies focus on systemic immunosuppression, which can leave patients vulnerable to infections.

In contrast, (TLSA) focuses on local modulation. By harnessing the body’s natural regulatory pathways, the company hopes to restore homeostasis in the brain without compromising the rest of the immune system.

Clinical Momentum and Market Positioning

The core thesis for Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) rests on its recent clinical validation and its unique position in the neuro-immunology sector.

On January 20, 2026, the company announced the peer-reviewed publicationof clinical study results for intranasal Foralumab, which showed signs of stabilizing disease progression and reducing microglial activation in patients with na-SPMS.

This publication in a respected medical journal provides a layer of scientific credibility that is essential for biotechnology firms approaching late-stage trials.

Targeting Massive Unmet Needs

The market potential for (TLSA) is substantial, as the global Multiple Sclerosis market is projected to be worth approximately $16.8B in 2026. Specifically, the non-active Secondary Progressive Multiple Sclerosis (na-SPMS) population represents a significant segment of patients—estimated at roughly 30% to 40% of all MS cases—who currently have no FDA-approved treatments.

By positioning Foralumab as a potential first-in-class therapy for this group, (TLSA) is entering an area with minimal direct competition and high demand.

The company is also moving aggressively into Alzheimer’s disease, having already dosed the first patient in a Phase 2 trial.

With the global Alzheimer’s market projected to grow over 300% from around $7.7B in 2026 to over $33.6B by 2034, a successful inflammation-based therapy could represent a massive therapeutic class.

Unlike treatments focused strictly on amyloid plaque removal, TLSA is targeting the neuroinflammation that often persists even after plaques are cleared.

This rapid market expansion, driven by a global aging population, suggests that even a small share of the Alzheimer’s market could be transformative for a clinical-stage firm.

Strengthened Financial and Leadership Support

Operational achievements have been matched by a bolstered balance sheet. In January 2026, (TLSA) closed an oversubscribed $8.8M registered direct offering, following a previous announcement of an offering up to $17.6M. This capital infusion is intended to fund the continued Phase 2a clinical trial of Foralumab.

Furthermore, the Executive Chairmanrecently increased his personal stake in the company, signaling strong internal confidence in the firm’s trajectory.

The company currently maintains a market capitalization of approximately $174M, with recent analyst notes highlighting that the current valuation may not fully reflect the potential of itsmulti-indication pipeline. With recent funding secured, (TLSA) has extended its runway to meet several high-impact data readouts expected throughout 2026.

Expert Management and Strategic Presence

The management team at TLSA consists of seasoned veterans from major pharmaceutical backgrounds. Executive Chairman Gabriele Cerrone has a history of founding and scaling successful biotech ventures, including companies later acquired by major players like Bristol Myers Squibb.

This level of experience is vital for navigating the complex regulatory and commercial hurdles of the FDA approval process.

Their presence was felt during the 9th Annual Neuroscience Innovation Forumheld during the J.P. Morgan Healthcare Conference week in San Francisco. This platform allowed the company to showcase its pipeline to global institutional observers and potential strategic partners. Engaging with the broader biotech community at such a critical venue underscores the company’s commitment to transparency and clinical progress.

Beyond MS: A Versatile Pipeline

While MS and Alzheimer’s are the leading programs, Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) is developing a platform, not just a single application. The company has clinical assets targeting ALS, a devastating condition with few viable treatments. Preclinical data suggests that the same Treg stimulation seen in MS could help slow the motor neuron degradation characteristic of ALS.

Additionally, the company owns rights toMilciclib (TZLS-201), an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs). Milciclib has already shown safety and tolerability in over 300 patients across Phase 1 and 2 trials for advanced solid cancers. By maintaining a diversified portfolio that includes bothoncology and neurodegenerative programs, (TLSA) mitigates the risk inherent in single-program biotech firms.

The company’s TZLS-501 program also explores the use of anti-interleukin-6 receptor (anti-IL6R) monoclonal antibodies. This asset is being explored for its potential to treat lung inflammation, demonstrating the breadth of the company’s intellectual property portfolio. The ability to pivot this technology to various inflammatory sites makes (TLSA)a versatile player in the immunotherapy space.

7 Reasons Why (TLSA) Will Be Topping Our Watchlist Tomorrow Morning—Monday, January 26, 2026…

1. Analyst Target: With an $8 targetfrom Lucid Capital Markets, (TLSA) is framed as having over 400% upside potential based on its recent range.

2. Chart History: Around this time last year, (TLSA) showed sharp volatility with an approximate 300% move in under 6 months, from around $0.65 to $2.60.

3. Peer Validation: A recent peer-reviewed publication of intranasal Foralumab results gives (TLSA)independent scientific support for its core approach.

4. Oversubscribed Funding: Anoversubscribed $8.8M registered direct offering in January 2026 provides (TLSA)added liquidity to pursue upcoming clinical milestones.

5. Insider Confidence: A recent increase in the Executive Chairman’s personal stake signals internal confidence at (TLSA) from someone closest to the program.

6. Clinical Momentum: Movement toward Phase 2 results in MS and Alzheimer’s keeps (TLSA) positioned around multiple 2026 data readouts tied to markets cited as roughly $16.8B for MS and about $33B for Alzheimer’s.

7. High-Profile Visibility: Participation during J.P. Morgan Healthcare Conference week in San Francisco helped place (TLSA) in front of institutional observers and potential partners.

Take A Close Look At (TLSA) Before Tomorrow Morning…

When you put the pieces together, (TLSA) checks several boxes that serious market watchers tend to prioritize: an analyst target that suggests over 400% upside potential, a demonstrated history of sharp swings, and a peer-reviewed publication supporting its intranasal Foralumab results.

Add in fresh capital from an oversubscribed $8.8M raise, an Executive Chairman increasing his personal stake, and ongoing Phase 2 momentum in both MS and Alzheimer’s—and you can see why attention is building.

The fact that (TLSA) also showed up during J.P. Morgan Healthcare Conference week only reinforces that it’s on more radar screens than it was before.

We will have all eyes on (TLSA) tomorrow morning.

Take a look at (TLSA) before you call it a night.

Also, keep a lookout for my morning update.

Have a good night.

Sincerely,

Gary Silver
Managing Editor,
Market Crux

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