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RJ Hamster

Compass Pathways Jumps 40% in Short Squeeze Rally

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This 4/20, Wall Street Is Betting on More Than Marijuana

Written by Jeffrey Neal Johnson on April 20, 2026

Key Points

A new executive order fast-tracking psychedelic medicines triggered single-session gains of roughly 40% for Compass Pathways and over 20% for Atai Beckley.
The cannabis sector has shifted away from speculative policy bets, with Curaleaf and Innovative Industrial Properties rewarding shareholders through buybacks and dividends.
A barbell strategy pairing high-growth psychedelic stocks against cash-generating cannabis operators could help balance risk and return in the alternative medicine space.
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While many investors focused on the annual 4/20 holiday, expecting the usual buzz around marijuana stocks, a quiet revolution was unfolding in Washington. Over a weekend when most of the market was logged off, the administration issued a bombshell executive order designed to fast-track psychedelic medicines to market.

This single catalyst has fundamentally cleaved the alternative drug sector in two. It has created a powerful new dynamic that separates high-octane growth opportunities from mature, value-oriented plays, leaving unprepared investors navigating a suddenly transformed landscape.

The market used to treat this entire space as one big, speculative bet on drug reform. That playbook is now obsolete. Today, a clear, bifurcated strategy has emerged for those looking to capitalize on the future of alternative medicine.

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From Trials to Takeoff: The FDA Fast-Track Ignites a Rally

The market’s reaction to the weekend news was immediate and forceful. Compass Pathways PLC (NASDAQ: CMPS), a leader in psilocybin therapy research, saw its stock jump roughly 40% in a single session. Similarly, Atai Beckley(NASDAQ: ATAI), which develops a diverse portfolio of mental health treatments, rose by more than 20%.

These explosive moves were amplified by a classic short-squeeze market dynamic. Prior to the announcement, many institutional investors were betting against these stocks, borrowing shares to sell them in the hopes of buying them back later at a lower price.

Short interest in Compass Pathways, for instance, had reached nearly 10% of its public float. The unexpected good news prompted short sellers to buy back shares and close their losing positions. This rush of forced buying pushed the stock price sharply higher.

Atai Beckley had a similar short interest of about 9.2%, suggesting it may have also been ripe for a short squeeze.

For investors, the administration’s new policy directly addresses the primary risk inherent in biotechnology: cash burn. Clinical trials are notoriously long and expensive. By creating a fast-track to commercialization, the government is effectively shortening the time these companies must spend burning through capital before generating revenue. This shift fundamentally de-risks the path to profitability by reducing the need for future dilutive financing and accelerating the timeline to potential positive cash flow.

The bull case is that with this powerful regulatory tailwind, the conversation shifts from if these companies can get their treatments to market to how quickly. The next 12 to 18 months could see companies like Compass and Atai accelerate their New Drug Application (NDA) submissions to the Food and Drug Administration.

An NDA is the formal step a drug sponsor takes to request that the FDA consider approving a new drug for marketing and sale. Securing an expedited review puts these companies on a direct course to secure commercial partnerships and begin tapping into a multi-billion-dollar mental health industry targeting conditions like treatment-resistant depression and PTSD. Still, investors should remain aware that these are pre-revenue companies, and their ultimate success remains tied to positive clinical outcomes and successful commercial execution.

Cannabis Grows Up: The New Focus on Profits, Not Policy

While psychedelic stocks were launching, the legacy cannabis sector experienced a much more subdued 4/20. The AdvisorShares Pure US Cannabis ETF (NYSEARCA: MSOS), a broad gauge of the industry, saw a modest bump. This muted reaction signals a critical evolution: the sector no longer trades solely on speculative legalization hype. Instead, the market is now rewarding tangible business fundamentals and shareholder returns.

The real story in cannabis lies with the operators generating significant cash for their investors. Consider these signs of corporate maturity:

Curaleaf Holdings (OTCMKTS: CURLF), a global revenue leader that generated over $333 million in its most recent quarter, announced a substantial share buyback program. For investors, a buyback is a strong signal of management’s confidence in the stock’s undervaluation. It also reduces the number of shares outstanding, thereby increasing earnings per share.
Innovative Industrial Properties (NYSE: IIPR) operates as a real estate investment trust (REIT). Simply put, IIPR is a landlord for licensed cannabis operators. It buys properties and leases them to growers, a model that insulates it from the volatility of plant-touching businesses. This strategy has proven profitable, allowing the company to generate over $111 million in profit and reward its shareholders with a husky 14% dividend yield.

The primary risk for cannabis investors has long been the slow pace of federal policy reform. However, companies like Curaleaf and IIPR are mitigating this risk by creating shareholder value now.

Looking ahead, the administration’s favorable stance on alternative medicines suggests the next logical catalysts are federal descheduling and the passage of crucial banking reform. Such legislation would clear the path for industry giants like Curaleaf to uplist from the over-the-counter (OTC) markets to major U.S. exchanges, such as the NASDAQ. An uplisting is a major validation that dramatically increases a stock’s liquidity and opens it up to a much larger pool of institutional investors and mutual funds.

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Balancing the Buzz: A Strategy for Psychedelics and Cannabis

The alternative drug market now presents two distinct and compelling paths. The weekend’s policy shockwave has supercharged the psychedelic sector, creating an explosive, policy-driven growth opportunity. This stands in sharp contrast to the cannabis sector, where industry leaders have graduated into mature value plays focused on generating cash and rewarding shareholders.

This bifurcation lends itself to a barbell strategy. This investment concept involves concentrating a portfolio on two extremes, in this case, high-growth speculation and stable value, with little in the middle. The high-growth potential of psychedelic stocks like Compass and Atai Beckley represents one side of the barbell. The other is anchored by the stability and cash flow of established cannabis operators like Curaleaf Holdings and Innovative Industrial Properties.

Ultimately, how an investor approaches this new landscape may depend on their individual strategy and risk tolerance. Those with a higher tolerance for risk and a focus on growth might find the policy-driven momentum in the psychedelic space compelling. Meanwhile, investors seeking value, income, and tangible fundamentals may gravitate toward the established cannabis companies that are already demonstrating solid profitability.

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RJ Hamster

The biggest rivalry in baseball is back

Tuesday, April 21

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Aaron Judge and Ben Rice lead the Yankees against Roman Anthony, Willson Contreras and the Red Sox.

Welcome to The Pregame Lineup, a weekday newsletter that gets you up to speed on everything you need to know for today’s games, while catching you up on fun and interesting stories you might have missed. Today’s edition is brought to you by David Adler.

Baseball’s No. 1 rivalry is back tonight.

The Yankees and Red Sox face off in a three-game series at Fenway Park, their first meeting since the 2025 American League Wild Card Series.

The Yanks got the best of Boston in that playoff matchup, taking down the Sox in a winner-take-all Game 3 at Yankee Stadium. The Bronx Bombers are also off to the better start this season — the Yankees enter this week’s showdown in first place in the AL East at 13-9, while the Red Sox are tied for last with the Blue Jays at 9-13.

Tonight’s series opener in Boston starts at 6:45 p.m. ET (TBS/MLB.TV), and you can find all the info on the rest of the series here.

But these are three big things we’ll be watching for:

1) Will New York’s 1-2 punch keep it going?

The Yankees have the top slugging duo in the Majors right now. One half of that duo is obviously Aaron Judge, whose nine home runs are one behind Yordan Alvarez for the MLB lead. The other half is Ben Rice, who’s building on his breakout 2025 with eight homers already in ’26 and an MLB-best 1.276 OPS. Judge and Rice have the most home runs of any pair of MLB teammates.

Rice has four home runs in 18 career regular-season games against the Red Sox (plus one in last year’s playoffs), while Judge has 34 home runs in 117 games against Boston (plus a pair in the 2018 postseason), easily the most of any active player against the Red Sox.

2) Can Roman Anthony get hot?

Anthony looked like a budding star as a rookie last season and in the World Baseball Classic this year for Team USA. But he hasn’t been at his best yet in 2026 — the 21-year-old is off to a .234 start at the plate with just one home run through his first 21 games. This would be a big series for Anthony to get going.

3) How will Cam Schlittler do in his first start at Fenway?

Speaking of young guns: Schlittler, who starts Thursday’s series finale for New York, has looked dominant to start the season (1.95 ERA, 36 strikeouts in five starts). And there’s going to be a lot of hoopla surrounding the 25-year-old flamethrower’s first career start at Fenway. Schlittler grew up a Red Sox fan in Massachusetts, and he’s embraced the Yanks-Sox rivalry — including stepping up in Game 3 of the Wild Card Series last October and eliminating the Red Sox with an eight-inning, 12-strikeout scoreless gem.

GAMES OF THE NIGHT

Besides Yankees-Red Sox, here are three games to watch tonight. For info on how to watch every game this season, go to MLB.com/Watch.

Reds at Rays (6:40 p.m. ET, MLB.TV)

The NL Central has been the best division in baseball so far this season. All five teams have a winning record — and leading the pack are the Reds in first place at 15-8. Cincinnati is on a four-game winning streak and sends breakout 23-year-old Chase Burns to the mound today.

Twins at Mets (7:10 p.m. ET, MLB.TV)

The Mets are on an 11-game losing streak, their worst since the 2004 season. If anyone can put a stop to it, it’s the team’s young ace, Nolan McLean, who gets the ball for the opener at Citi Field. The electric rookie has a 2.28 ERA and 28 strikeouts in 23 2/3 innings through four starts and just went pitch-for-pitch with Dodgers ace Yoshinobu Yamamoto his last time out.

If McLean can play stopper, a huge reinforcement is coming for the Mets after that: Juan Soto should be back from the injured list tomorrow, a source told MLB.com’s Anthony DiComo.

Dodgers at Giants (9:45 p.m. ET, MLB.TV)

Yankees-Red Sox isn’t the only rivalry series this week. The Dodgers and Giants, who form another one of MLB’s classic rivalries, also meet for the first time this season starting tonight. The player to watch for L.A. in this one is Yamamoto, who’s pitching like a Cy Young contender.

J-ROD VS. A 108 MPH KNUCKLEBALL

Julio Rodríguez pulled off one of the craziest catches of the year in center field in Seattle yesterday. Just watch:

An animated GIF of Julio Rodríguez's catch vs. a knuckleball line drive

No, you’re not seeing things. It’s not an optical illusion. That line drive off the bat of Nick Kurtz really was a knuckleball. A 108 mph knuckleball.

It started off as a frozen rope to Rodríguez’s left, only to tail back at the last second to his right. But the Mariners star made an incredible recovery to make the grab.

Here’s what the trajectory of the ball looked like, using Statcast’s 3D tracking:

An animated GIF with Statcast 3D tracking of Julio Rodríguez's catch

Luckily for Seattle, nothing escapes J-Rod’s No Fly Zone. Not even that witchcraft.

WHO SHOULD CLOSE FOR DÍAZ-LESS DODGERS?

The Dodgers might have MLB’s best record at 16-6, but the defending champs just took a big blow: closer Edwin Díaz, one of the team’s marquee free-agent signings this offseason, is having surgery to remove loose bodies from his pitching elbow and won’t be back until after the All-Star break.

So who should close for the Dodgers in Díaz’s absence? They haven’t named a replacement closer, but here are the big three arms who could combine to fill the role. (Spoiler: It’s not going to be Roki Sasaki.)

1) LHP Tanner Scott

Scott was supposed to be the Dodgers’ closer last year, but he struggled in his first season in L.A. and couldn’t hold onto the job. But Scott’s been much better in 2026, with a 1.04 ERA through 10 outings and eight strikeouts with zero walks. He could get another crack at the ninth.

2) LHP Alex Vesia

One of the Dodgers’ most reliable arms out of the ‘pen, Vesia has yet to allow a run this season in 10 appearances and has 10 K’s in 8 2/3 innings. The veteran southpaw has one of the best rising fastballs in baseball and L.A. often looks to him to get the biggest outs of a game.

3) RHP Blake Treinen

Treinen was Old Reliable for the Dodgers for so long. Now 37 years old, he’s still a strong late-inning option with his vintage sinker-sweeper combo, and had started the season with eight straight scoreless outings before a rocky one against the Rockies on Sunday.

STREAK TRACKER

There are two big streaks going around the Majors right now. We’re keeping track of them here.

Shohei Ohtani’s on-base streak

Currently at: 52 games

AL/NL record: Ted Williams, 84 games (1949)

Ohtani extended his streak to 52 consecutive games yesterday with a third-inning single off the Rockies’ Jose Quintana. With one more game, Ohtani will tie Shawn Green (2000) for the second-longest streak in Dodgers history. (Duke Snider has the longest at 58 games in 1954.)

Fun fact: Shohei has now passed Babe Ruth’s career-best 51-game on-base streak from 1923.

Mason Miller’s scoreless innings streak

Currently at: 32 2/3 innings

AL/NL record: Orel Hershiser, 59 innings (1988)

Reliever record (Expansion Era): Gregg Olson, 41 innings (1989-90)

The Padres were off yesterday, so Miller’s streak stays one inning shy of Cla Meredith’s franchise record. San Diego faces the Rockies tonight at 8:40 p.m. ET (MLB.TV).

THE DODGERS x CONVERSE: LA EDITION

Yoshinobu Yamamoto holding the LA Dodgers Chuck 70 shoe

Last week, the Dodgers dropped a collab with Converse and UNDEFEATED, introducing the Brooklyn Dodgers Chuck 70 — a new version of the classic Chuck Taylor All-Star shoe in honor of the back-to-back World Series champs.

Today, Part 2 of the collab dropped: A Los Angeles Dodgers edition, featuring the Dodgers’ iconic “LA” logo instead of the Brooklyn “B.” (The drop also features Yoshinobu Yamamoto introducing the shoe.)

The LA variation launches this Saturday at UNDEFEATED physical stores and Undefeated.com. The shoe will then be available at converse.com, MLBShop.com, the MLB Flagship Store in NYC and the Dodgers Team Store next Monday.

Bryan Horowitz has the story on Converse and UNDEFEATED’s love letter to Dodgers culture.

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RJ Hamster

Espresso Elevated: What’s Brewing at Jojo? ☕

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Espresso Elevated: What’s Brewing at Jojo? ☕

Where flow meets the game.

Tuesday, April 21

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Flow can’t be explained, it’s felt. Players, fans and culture push the game beyond nine innings. El Béisbol es Otra Cosa.

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‘El Jocho’

Enrique Olvera is a world-renowned Mexican chef, known for Pujol and his impact on global fine dining. His work transforms the everyday into culture, bringing new flavor to the game con puro flow.

Learn more >>

Mexico City Series 2026

The Padres and D-backs meet at Estadio Alfredo Harp Helú on Saturday at 6pm ET and Sunday at 4pm ET during the Mexico City Series presented by

T-Mobile. Where to watch >>

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RJ Hamster

Tee Up with the Best: AZ’s Top Cannabis Golf…

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Tee Up with the Best: AZ’s Top Cannabis Golf Event 🏌️‍♂️

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RJ Hamster

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The parts of us that feel broken or unfinished are often the very places where the most growth takes root. What feels like a crack in your story might actually be an opening—a place where new understanding, new strength, and new purpose can pour in. Don’t hide those places. They are part of what makes your journey so remarkable and so real.MORE INSPIRATION

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RJ Hamster

Today’s Blessing

Today’s Blessing
April 21, 2026

You are not behind. You are not too late. The timing of your life is not a mistake. What is meant for you will not pass you by — and every twist in the road has been shaping you into someone ready to receive it.TRUST YOUR TIMING

Discover Your Path

Today’s Blessing is here to guide you through life’s twists and turns, helping you become the best version of yourself and fulfill your destiny.✨Angel NumbersAngel numbers are divine affirmations from the universe, giving us signs we’re on the right track and that we’re not alone.CONTINUE →🙏Faith MessagesHear stories from around the world that will help motivate and bring positivity to your life’s journey.CONTINUE →💫InspirationEmpowering and inspirational stories. See some of these tips from our friends to set you on the pathway to success.CONTINUE →

You’re always one blessing away from a brighter day… and a bigger life. May these stories, affirmations, prayers, and insights lift your spirits and inspire you to lift others.

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