This Rare Disease Biotech Has a Strategy That Works

Before biotech companies make headlines, they build strong foundations. This one has both.

Its lead drug is already fast-tracked by the FDA for several rare childhood diseases. Now, it’s preparing for Phase 2 trials-and the structure behind this company makes it stand out.

With the science to its successful backers, it is following a proven biotech playbook-and Main Street investors can now get involved.

See Why This Strategy Stands Out

GameStop Partying Like It’s 2021: What’s Behind Its 2025 Rebound?

Written by Dan Schmidt. Published 9/22/2025.

The carnival is back at GameStop Inc. (NYSE: GME) in 2025, as the stock has reclaimed its meme status. As before, steep drawdowns followed blockbuster rallies, and GME frequently trended on social media.

However, the peaks and valleys haven’t been as extreme, and this year’s two major uptrends appear to have opposing catalysts.

What’s driving this revival, and is any of it sustainable? If you’re hoping for a 2021 repeat, you may be disappointed.

Still, GameStop is demonstrating something it never did in 2021: improving fundamentals.

Collectibles Fuel Fundamental Improvements

If you own a mint-condition Ken Griffey Jr. rookie card, your patience—or neglect—has paid off. Trading-card collectibles have surged in value, swelling into a $13 billion market in 2025, with an expected compound annual growth rate (CAGR) of 8%.

Unlike NFTs or digital assets, trading cards are tangible items that require physical locations for transactions.

Is this trend bringing customers back into brick-and-mortar stores?

Just ask Target, which limited Pokémon card sales due to safety concerns. Consumers are showing renewed enthusiasm for collectibles, and GameStop has pounced on this resurgence by expanding its collectibles business.

In its Q2 2025 earnings report on Sept. 9, GameStop beat both EPS and revenue estimates—the first top- and bottom-line beat since Q2 2023—and delivered nearly 22% year-over-year (YOY) revenue growth.

The collectibles division surged 63% YOY to $228 million. Hardware sales jumped 31% to nearly $600 million, and the company’s Bitcoin holdings approached $530 million by quarter’s end.

GME shares have gained momentum since the report, rising 13% over the past 30 days.

Current Rally vs. May Price Spike

GME shares spiked to a 2025 high in early May, but that rally proved more fluff than substance. The initial surge followed the announcement of a crypto treasury strategy, including plans to buy Bitcoin.

The rally intensified when CEO Ryan Cohen posed with cryptocurrency advocate and MicroStrategy Inc. (NASDAQ: MSTR) CEO Michael Saylor. GME shares jumped from $22 to $36 in two months, driven mainly by social-media speculation and high short-interest narratives.

At that point, the company hadn’t purchased any Bitcoin and had missed revenue expectations in Q4 2024 and Q1 2025.

That rally fizzled quickly, with the stock returning to $22 per share in under three weeks.

Trading has been choppy in 2025, but this recent rally appears supported by both fundamental and technical factors. The positive earnings were preceded by building momentum on the daily chart’s Moving Average Convergence Divergence (MACD).

Despite a Death Cross and three months of range-bound trading, the MACD signaled a potential move higher—and now GME is breaking above its 50-day and 200-day simple moving averages (SMAs).

The previous rally also featured a bullish MACD crossover before the stock price cleared those SMAs. The area around the 200-day SMA will be crucial in the coming sessions; a meaningful breakout could spark another wave of retail buying.

Upward Momentum Could Be Capped, So Trade Carefully

Despite improved fundamentals and technical tailwinds, GME is likely constrained by business realities. The booming collectibles division still accounts for only 25% of total revenue, and the uptick in hardware sales may not be sustainable.

GameStop regularly topped $1 billion in quarterly revenue between 2015 and 2023, including multiple pandemic quarters. Since Q4 2023, it has surpassed that threshold only once—a concerning sign in a healthy consumer environment.

The stock also remains vulnerable to crypto volatility, given its Bitcoin holdings, and to meme-stock sentiment on social media. Despite several rallies this year, GME is down 17% year-to-date, underscoring the fleeting nature of its bullish runs.

Until GameStop can prove its fundamental turnaround is sustainable, GME remains a stock to trade, not one to invest in for the long term.