The Holladay Distillery was founded in 1856, making it both the oldest distillery in the state of Missouri and the oldest distillery west of the Mississippi still operating on its original site. The property sits on active limestone springs that were first charted by Lewis and Clark in 1804, more than fifty years before Ben Holladay purchased the land that would later become his legacy.

Ben Holladay Bourbon is classified as a Real Missouri Bourbon under a 2019 law requiring that any whiskey labeled as Missouri bourbon must not only meet the federal standards for bourbon, but also be mashed, fermented, distilled, aged, and bottled in the state; aged in oak barrels manufactured in the state; and—beginning January 1, 2020—made with corn exclusively grown in the state.